Publications

@article{pmid40714359,

title = {Synthetic mid-urethral slings in female spina bifida patients with stress urinary incontinence: Is it worth it?},

author = {Alicia Blondeau and Samia Laraqui and Goncalo Mendes and Juliette Hascoet and Camille Haudebert and Charlène Brochard and Claire Richard and Caroline Voiry and Laurent Siproudhis and Krystel Nyangoh Timoh and Andrea Manunta and Emmanuelle Samson and Benoit Peyronnet},

doi = {10.1016/j.fjurol.2025.102938},

issn = {2950-3930},

year  = {2025},

date = {2025-12-01},

journal = {Fr J Urol},

volume = {35},

number = {13-14},

pages = {102938},

abstract = {INTRODUCTION: The aim of this study was to report the outcomes of synthetic mid-urethral slings (MUS) in female patients with spina bifida and stress urinary incontinence (SUI).nnMETHODS: All female patients with spina bifida who were seen at a national referral center between 2007 and 2021 and who had a history of MUS for SUI were included in a retrospective study. The primary outcome of interest was the continence status at 1year as per patients' subjective perception categorized as complete continence, improved continence, unchanged or worsened SUI.nnRESULTS: Out of 339 female spina bifida patients; 11 patients had undergone a MUS insertion and were included for analysis (3.2%). The median age was 30years (range: 19-52years). There were four postoperative complications (36.4%). The three patients fully continent at three months were still fully continent at one year (27.3%) while three had improved continence (27.3%) and five had unchanged continence (45.5%). After a median follow-up of 102months, only one patient was still fully continent (9.1%) and three patients had still improved continence (27.3%). Five patients (45.5%) underwent a subsequent anti-incontinence procedure. The only adverse predictor of improved/complete continence at 1year was a sacral neurological level (OR=0.05; p=0.03).nnCONCLUSION: MUS in women with spina bifida and SUI appears to be safe but less effective than in the non-neurogenic population which may be explained by different underlying pathophysiological mechanisms. These findings question the relevance of this treatment option in these complex population, especially in the current mesh controversy era.},

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@article{pmid40536621,

title = {Severe scoliotic deformities: results of surgical treatment and complications in a multicentric series of children and young adults},

author = {Alice Baroncini and Aude Kerdoncuff and Daniel Larrieu and Cedric Barrey and Federico Solla and Christian Morin and Corinne Bronfen and Adele Hapiette and Gauthier Eloy and Richard La Croix and Thierry Odent and Ibrahim Obeid},

doi = {10.1007/s43390-025-01122-y},

issn = {2212-1358},

year  = {2025},

date = {2025-11-01},

journal = {Spine Deform},

volume = {13},

number = {6},

pages = {1799--1810},

abstract = {PURPOSE: The surgical management of severe spinal deformities (> 80°) in children and young adults remains challenging despite technical advances. Large, stiff curves with a short radius present a high complication rate, also in terms of acute or chronic spinal cord injury. There is a lack of consensus regarding the perioperative management of these curves, also due to the limited evidence available. This study aimed to review the strategies used in different hospitals for the surgical management of severe spinal deformities in young subjects and, in particular, to analyze the complication rate in a large series of patients.nnMETHODS: Multicentric, retrospective study on surgically treated patients younger than 25 with a coronal or sagittal deformity measuring at least 80°. Perioperative and radiographic data were collected. The rate of mechanical, neurologic, infectious, and other complications was analyzed, along with possible risk factors.nnRESULTS: Data from 161 patients were analyzed. After surgery, there was a significant improvement of the deformity both on the coronal and sagittal plane. The overall complication rate was 25%. An increased angular ratio in the first postoperative X-ray was the main risk factor for the development of complications, along with a higher correction of the spinosacral angle. Performing a 3CO was associated with a higher risk of infections but not with a higher risk of mechanical complications. The use of an anterior approach did not increase the complication rate. A higher rate of non-mechanical and non-infectious complications was observed in patients who did not wear a brace or did not undergo halo traction before surgery.nnCONCLUSION: While spinal fusion is an effective treatment for the management of severe deformities, the rate of complications is still high.},

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pubstate = {published},

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@article{pmid40915611,

title = {Spinal cord malformations's epidemiology in French children: National cross sectional study based on medico-administrative database},

author = {C Hervet and C Le Roux and C Gaborit and J Maheut-Lourmiere and C Fremont and H Lardy and L Grammatico-Guillon and T Odent},

doi = {10.1016/j.neuchi.2025.101713},

issn = {1773-0619},

year  = {2025},

date = {2025-11-01},

journal = {Neurochirurgie},

volume = {71},

number = {6},

pages = {101713},

abstract = {OBJECTIVE: Epidemiological data on rare spinal cord malformations in children are lacking in France. Using the national hospital discharge database (PMSI), we studied the care trajectories and estimated the morbidity and mortality burden of these conditions.nnSTUDY DESIGN: We conducted a nationwide historical cohort study from 2010 to 2020, including children diagnosed with rare spinal cord diseases within the scope of the C-MAVEM network. Cases were identified through ICD-10 codes using a semi-automated, multicenter-validated extraction algorithm (positive predictive value >80%). Incidence and in-hospital mortality rates were estimated for the following conditions: Spina Bifida (SB), Arnold Chiari syndrome (ACS), Syringomyelia and Syringobulbia (SM), Diastematomyelia (DM), and Hydromyelia (HM).nnRESULTS: A total of 10,114 children were identified, corresponding to an estimated prevalence of 67 per 100,000. Incidence rates per 100,000 live births were: 2.6 for SB, 2.2 for ACS, 1.0 for SM, 0.2 for DM, and 0.04 for HM. The mortality was 2.5%, 1.7%, 1.1%, 0.95%, no available for HM, respectively. Most patients were treated in university hospitals with considerable heterogeneity in surgical management depending on etiology and associated malformations.nnCONCLUSION: This study provides, for the first time in France, national epidemiological estimates for rare pediatric spinal cord malformations. The use of a validated medico-administrative data extraction approach enables largescale surveillance of these rare conditions, improves understanding of their healthcare burden, and supports planning for specialized care and public health strategies.},

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@article{pmid41293758,

title = {Pelvic organ prolapse is highly prevalent in women with spina bifida},

author = {Alexandre Dubois and Briac Malandain and Juliette Hascoet and Camille Haudebert and Charlène Brochard and Claire Richard and Caroline Voiry and Krystel Nyangoh Timoh and Andrea Manunta and Emmanuelle Samson and Benoit Peyronnet},

doi = {10.1002/bco2.70113},

issn = {2688-4526},

year  = {2025},

date = {2025-11-01},

journal = {BJUI Compass},

volume = {6},

number = {11},

pages = {e70113},

abstract = {INTRODUCTION: Women with spina bifida often experience neurological impairments leading to pelvic organ dysfunction, including difficulties with bladder and bowel emptying that necessitate frequent Valsalva manoeuvres. These factors, combined with pelvic floor weakness, may increase the risk of pelvic organ prolapse (POP). This study aimed to assess the prevalence of POP in women with spina bifida, identify associated risk factors and evaluate outcomes of surgical management.nnMETHODS: We retrospectively analysed a prospectively maintained database of women with spina bifida seen at a French referral centre from 2007 to 2024. Age under 18 and congenital perineal abnormality were exclusion criteria. The primary outcome was the presence of POP grade 2 or higher (Baden-Walker classification). Secondary outcomes included symptomatic POP requiring surgery, recurrence after surgery, use of vaginal pessaries and related symptoms.nnRESULTS: POP grade ≥2 was present in 14.8% of patients. Women with POP were older (median 44 vs. 31 years; p < 0.0001) and more frequently parous (58.5% vs. 18.3%; p < 0.0001), although 41.5% of POP cases occurred in nulliparous women. Apical prolapse was predominant (64.3%). Among 11 patients who underwent POP surgery, 54.5% experienced recurrence. Multivariate analysis identified parity (OR 5.33; p = 0.005) and lower maximum urethral closure pressure (OR 0.97; p = 0.02) as independent risk factors.nnCONCLUSIONS: POP is highly prevalent in young adult women with spina bifida, including many nulliparous patients. The parity status and a low maximum urethral closure pressure could be associated with an increased risk of POP in this population. High recurrence after surgery highlights the need for information, routine screening and tailored management in this population.},

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pubstate = {published},

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@article{pmid41046909,

title = {[Fetoscopic myelomeningocele repair (with video)]},

author = {Lucie Guilbaud and Timothée de Saint Denis and Sabine Irtan and Jean-Marie Jouannic},

doi = {10.1016/j.gofs.2025.09.087},

issn = {2468-7189},

year  = {2025},

date = {2025-10-01},

journal = {Gynecol Obstet Fertil Senol},

keywords = {},

pubstate = {published},

tppubtype = {article}

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@article{pmid41085564,

title = {Global and segmental thoracolumbar sagittal alignment in adolescent idiopathic scoliosis compared to normal individuals},

author = {Guillaume Battesti and Lucas Chomienne and François Severac and Mickael Finoco and Emmanuelle Ferrero and Marc Khalifé and Thierry Odent and Edouard de Charnace and Sebastien Pesenti and Solène Prost and Benjamin Blondel and Federico Solla and Mourad Ould-Slimane and Brice Illhareborde and Yann Philippe Charles},

doi = {10.1007/s00586-025-09436-1},

issn = {1432-0932},

year  = {2025},

date = {2025-10-01},

journal = {Eur Spine J},

abstract = {OBJECTIVE: To quantify differences of global and segmental sagittal thoracolumbar alignment between normal individuals and adolescent idiopathic scoliosis (AIS) according to primary curve types.nnMETHODS: Radiographic parameters were compared between 1115 normal adolescents and young adults versus 1779 AIS. Thoracic kyphosis (T1-T12), lumbar lordosis (L1-S1), segmental alignment (T1-T5, T5-T10), thoracolumbar junction (T10-L1), segmental lordosis (L1-L4, L4-S1), lumbar and thoracic apex, thoracolumbar inflection point, global alignment parameters (SVA C7, SVA C2, OD-HA, TPA, GT, SSA) and pelvic parameters (PI, PT, SS) were measured.nnRESULTS: C2 and C7 SVA was smaller and more posteriorly located in AIS compared to normal. Primary thoracic curves (Lenke 1, 2 and 3) had the lowest TK at T5-T10 compared to normal and primary thoracolumbar curves (Lenke 5 and 6). The thoracolumbar junction T10-L1 was smallest and slightly lordotic in Lenke 1 and 2. Distal lordosis L4-S1 and PI were highest in thoracolumbar curves (Lenke 3, 5 and 6). Thoracolumbar inflexion points, thoracic and lumbar apex were located more cranial in thoracic curves (Lenke 1 and 2) compared to normal and other AIS types.nnCONCLUSION: Thoracic curves (Lenke 1 and 2) were hypokyphotic in the distal thoracic segment T5-T10, had a neutral thoracolumbar junction T10-L1 and their apex and thoracolumbar junction were more cranial. Lenke 3 curves had an increased lordosis in the distal lumbar segment L4-S1. Primary lumbar curves (Lenke 5 and 6) had a higher PI and distal lordosis L4-S1, and the highest C7 SVA.},

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pubstate = {published},

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@article{pmid40629359,

title = {Revised orphanet nomenclature and classification for spina bifida and other spinal dysraphisms (SBoD)},

author = {Ferdinand Dhombres and Timothée de Saint-Denis and Dominic Thompson and Julie Tahraoui-Bories and Caterina Lucano and Ana Rath and Giovanni Mosiello and Jean-Marie Jouannic and  and  and  and },

doi = {10.1186/s13023-025-03856-4},

issn = {1750-1172},

year  = {2025},

date = {2025-07-01},

journal = {Orphanet J Rare Dis},

volume = {20},

number = {1},

pages = {348},

abstract = {BACKGROUND: The Spina Bifida and other Dysraphisms working group (SBoD WG) is an interdisciplinary group, comprising experts on spinal dysraphism from 11 European countries. In 2022, the SBoD WG was tasked by 2 European Rare Disease Networks (ERN ITHACA and ERN eUROGEN) to revise the Orphanet classification of spinal dysraphism. Over the past two decades numerous subcategories of spinal dysraphism have been described in the medical literature resulting in a proliferation of terms, numerous synonyms and variously applied definitions. In the light of this, a revision of all terms and definitions was conducted by a Delphi approach in 3 steps by neurosurgeons (fetal/paediatric/adult), urologists (paediatric/adult), rehabilitation medicine specialists, fetal medicine and perinatal imaging specialists, geneticists, pathologists, nephrologists and patient representatives, all members of the International Federation for Spina Bifida and Hydrocephalus (IFSBH).nnRESULTS: In the first instance, 39 experts reviewed and refined the terminology that could be used to describe the anatomical characteristics of all forms of SBoD. At the second stage, 24 experts established terms and unambiguous definitions for 16 skin findings, 7 bone findings and 33 spinal cord findings that were considered essential features capable of describing all forms of spinal dysraphism. In the third stage, 29 experts validated 24 spinal dysraphic anomalies using these pre-agreed findings. All terms and definitions were validated by vote with a threshold of 80% approval (abstention was permitted). No terms with disagreement were retained in the subsequent classification. The revised SBoD classification was transferred to the Orphanet nomenclature (ORPHA:823). 16 existing ORPHAcodes were deemed obsolete, 10 ORPHAcodes were updated (terms and/or textual definitions) and 25 new ORPHAcodes were created. The SBoD working group also developed a 'decision tree' for new users, to assist them in the practical aspects of applying the revised classification and designating appropriate ORPHAcodes.nnCONCLUSIONS: An update of the Orphanet Classification of spinal dysraphism was conducted by a European interdisciplinary group of experts encompassing all aspects of healthcare for patients with these disorders. This new classification, based on essential skin, bone and spinal cord findings offers a more logical and reproducible means to categorise SBoD. It is hoped that this will permit more precise disease delineation, consistent diagnostic accuracy and better prognostication.},

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pubstate = {published},

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@article{pmid39362523,

title = {Spine to pelvis "T-Construct" using magnetic controlled growing rods in non-walkers neuromuscular early-onset scoliosis: a preliminary study},

author = {Clélia Thouement and Elie Saghbini and Gauthier Eloy and Raphaël Pietton and Raphaël Vialle and Tristan Langlais},

doi = {10.1016/j.otsr.2024.104012},

issn = {1877-0568},

year  = {2025},

date = {2025-05-01},

journal = {Orthop Traumatol Surg Res},

volume = {111},

number = {3},

pages = {104012},

abstract = {BACKGROUNDS: Magnetic controlled growing rods (MCGRs) have been proven to be effective in controlling early onset neuromuscular scoliosis but no study has evaluated the combination with a sacro-bi-iliac construct. The aim of our study is to report surgical management of early onset non-walkers neuromuscular scoliosis correction using MCGRs associated with a sacro-bi-iliac "T-construct" and its mid-term outcomes. Our hypothesis was that this set-up provided well correction of the pelvic obliquity and that this correction was maintained over time.nnMETHODS: A retrospective single-center study was conducted including all consecutive neuromuscular early onset scoliosis who underwent spinopelvic fixation using "T-construct" with two MCGRS. Four millimeters lengthening was performed every 4 months during outpatient clinics sessions. All children had a low-dose biplanar stereoradiography in EOS-Chair at pre/postoperative phase, each outpatient clinic appointment and last follow-up.nnRESULTS: Eighteen patients were included and 17 analyzed at the last follow-up. The mean age at surgery was 9.5 (range from 5 to 12 years), the mean follow-up was 4,7 years (range from 2.5 to 6.6 years) and 8 patients had a Risser stage above four. The global complication rate was 35% (N = 6/17 patients) including three medical and three mechanical complications related to "T-construct", while the reoperation rate was 18% (N = 2 patients for wound debridement and one for iterative pelvic fixation). Cobb angle and pelvic obliquity were significantly improved by surgery (mean correction was 33.2 ° (55%) and 11 ° (77%) respectively; p < 0.001). At the last follow-up, we noted a loss of frontal Cobb angle correction (p < 0.01) whereas we did not observe any significant loss of pelvic obliquity (p > 0.9).nnCONCLUSIONS: Although the global complication rate was 35% (half of which are mechanical complications), the treatment combining pelvic T-construct and MCGRs provides satisfactory correction of pelvic obliquity correction, good maintenance in the medium term and may be a procedure to consider for the surgical treatment of early onset neuromuscular scoliosis.nnLEVEL OF EVIDENCE: IV; Retrospective cohort prognostic study.},

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