Rougereau, Grégoire; Marty-Diloy, Thibault; Vigan, Marie; Donadieu, Kalinka; Hardy, Alexandre; Vialle, Raphaël; Langlais, Tristan
Dans: Foot Ankle Int, vol. 43, no. 6, p. 840–849, 2022, ISSN: 1944-7876.
@article{pmid35373593,
title = {A Preliminary Study to Assess the Relevance of Shear-Wave Elastography in Characterizing Biomechanical Changes in the Deltoid Ligament Complex in Relation to Ankle Position},
author = {Grégoire Rougereau and Thibault Marty-Diloy and Marie Vigan and Kalinka Donadieu and Alexandre Hardy and Raphaël Vialle and Tristan Langlais},
doi = {10.1177/10711007221079829},
issn = {1944-7876},
year = {2022},
date = {2022-06-01},
journal = {Foot Ankle Int},
volume = {43},
number = {6},
pages = {840--849},
abstract = {BACKGROUND: The purpose of this study was (1) to evaluate the biomechanical properties of the different bundles of the deltoid ligament in various ankle positions in a cohort of healthy adult volunteers; (2) describe the impact of demographic and hindfoot morphology characteristics on their stiffness; (3) to assess the reliability and reproducibility of these measurements.nnMETHODS: Deltoid ligament complex of both ankles were assessed by shear-wave elastography (SWE) in 20 healthy patients resting on hinge support. The propagation shear-wave speed (SWS) in ligaments was measured, which is related to the tissue's elastic modulus. The following ligaments were analyzed in a neutral position and then in varus, valgus, dorsal, and plantar flexions: tibionavicular ligament (TNL), tibiocalcaneal ligament (TCL), the superficial posterior tibiotalar ligament (SPTL), the anterior tibiotalar ligament (ATTL), and the deep posterior tibiotalar ligament (DPTTL).nnRESULTS: The mean SWS increased between neutral and 20 degrees valgus position for TCL (4.08 ± 0.78 m/s vs 5.56 ± 0.62 m/s, respectively; < .0001) and for DPTTL (2.58 ± 0.52 m/s vs 3.59 ± 0.87 m/s, respectively; < .0001). The mean SWS increased between neutral and 30 degrees plantarflexion for ATTL (2.11 ± 0.44 m/s vs 3.1 ± 0.5 m/s, respectively; < .0001) and TNL (2.96 ± 0.66 m/s vs 4.99 ± 0.69 m/s, respectively; < .0001). The mean SWS increased between neutral and 20 degrees dorsal flexion for SPTL (4.2 ± 1 m/s vs 5.45 ± 0.65 m/s, respectively; < .0001).Women had less DPTTL SWS than men in the neutral position (2.37 ± 0.35 m/s vs 2.71 ± 0.49 m/s, respectively; = .007). Other demographics had no impact on the SWS value of other ligaments. All inter- and intraobserver agreements were good to excellent.nnCONCLUSION: This study presents a reliable and reproducible SWE measurement protocol to describe the physiological function of all bundles of the medial collateral ligament in healthy adults.nnCLINICAL RELEVANCE: This examination technique can be available to orthopaedic surgeons, allowing reliable and reproducible monitoring of the SWS of the various ligaments constituting the medial collateral plane. The biomechanical values described in this study may give insight into in what position medial ankle ligament reconstruction should be tensioned.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: The purpose of this study was (1) to evaluate the biomechanical properties of the different bundles of the deltoid ligament in various ankle positions in a cohort of healthy adult volunteers; (2) describe the impact of demographic and hindfoot morphology characteristics on their stiffness; (3) to assess the reliability and reproducibility of these measurements.nnMETHODS: Deltoid ligament complex of both ankles were assessed by shear-wave elastography (SWE) in 20 healthy patients resting on hinge support. The propagation shear-wave speed (SWS) in ligaments was measured, which is related to the tissue’s elastic modulus. The following ligaments were analyzed in a neutral position and then in varus, valgus, dorsal, and plantar flexions: tibionavicular ligament (TNL), tibiocalcaneal ligament (TCL), the superficial posterior tibiotalar ligament (SPTL), the anterior tibiotalar ligament (ATTL), and the deep posterior tibiotalar ligament (DPTTL).nnRESULTS: The mean SWS increased between neutral and 20 degrees valgus position for TCL (4.08 ± 0.78 m/s vs 5.56 ± 0.62 m/s, respectively; < .0001) and for DPTTL (2.58 ± 0.52 m/s vs 3.59 ± 0.87 m/s, respectively; < .0001). The mean SWS increased between neutral and 30 degrees plantarflexion for ATTL (2.11 ± 0.44 m/s vs 3.1 ± 0.5 m/s, respectively; < .0001) and TNL (2.96 ± 0.66 m/s vs 4.99 ± 0.69 m/s, respectively; < .0001). The mean SWS increased between neutral and 20 degrees dorsal flexion for SPTL (4.2 ± 1 m/s vs 5.45 ± 0.65 m/s, respectively; < .0001).Women had less DPTTL SWS than men in the neutral position (2.37 ± 0.35 m/s vs 2.71 ± 0.49 m/s, respectively; = .007). Other demographics had no impact on the SWS value of other ligaments. All inter- and intraobserver agreements were good to excellent.nnCONCLUSION: This study presents a reliable and reproducible SWE measurement protocol to describe the physiological function of all bundles of the medial collateral ligament in healthy adults.nnCLINICAL RELEVANCE: This examination technique can be available to orthopaedic surgeons, allowing reliable and reproducible monitoring of the SWS of the various ligaments constituting the medial collateral plane. The biomechanical values described in this study may give insight into in what position medial ankle ligament reconstruction should be tensioned.
Prenatal phenotyping: A community effort to enhance the Human Phenotype Ontology
Dhombres, Ferdinand; Morgan, Patricia; Chaudhari, Bimal P; Filges, Isabel; Sparks, Teresa N; Lapunzina, Pablo; Roscioli, Tony; Agarwal, Umber; Aggarwal, Shagun; Beneteau, Claire; Cacheiro, Pilar; Carmody, Leigh C; Collardeau-Frachon, Sophie; Dempsey, Esther A; Dufke, Andreas; Duyzend, Michael Henri; Ghosh, Mirna El; Giordano, Jessica L; Glad, Ragnhild; Grinfelde, Ieva; Iliescu, Dominic G; Ladewig, Markus S; Munoz-Torres, Monica C; Pollazzon, Marzia; Radio, Francesca Clementina; Rodo, Carlota; Silva, Raquel Gouveia; Smedley, Damian; Sundaramurthi, Jagadish Chandrabose; Toro, Sabrina; Valenzuela, Irene; Vasilevsky, Nicole A; Wapner, Ronald J; Zemet, Roni; Haendel, Melissa A; Robinson, Peter N
Dans: Am J Med Genet C Semin Med Genet, vol. 190, no. 2, p. 231–242, 2022, ISSN: 1552-4876.
@article{pmid35872606,
title = {Prenatal phenotyping: A community effort to enhance the Human Phenotype Ontology},
author = {Ferdinand Dhombres and Patricia Morgan and Bimal P Chaudhari and Isabel Filges and Teresa N Sparks and Pablo Lapunzina and Tony Roscioli and Umber Agarwal and Shagun Aggarwal and Claire Beneteau and Pilar Cacheiro and Leigh C Carmody and Sophie Collardeau-Frachon and Esther A Dempsey and Andreas Dufke and Michael Henri Duyzend and Mirna El Ghosh and Jessica L Giordano and Ragnhild Glad and Ieva Grinfelde and Dominic G Iliescu and Markus S Ladewig and Monica C Munoz-Torres and Marzia Pollazzon and Francesca Clementina Radio and Carlota Rodo and Raquel Gouveia Silva and Damian Smedley and Jagadish Chandrabose Sundaramurthi and Sabrina Toro and Irene Valenzuela and Nicole A Vasilevsky and Ronald J Wapner and Roni Zemet and Melissa A Haendel and Peter N Robinson},
doi = {10.1002/ajmg.c.31989},
issn = {1552-4876},
year = {2022},
date = {2022-06-01},
journal = {Am J Med Genet C Semin Med Genet},
volume = {190},
number = {2},
pages = {231--242},
abstract = {Technological advances in both genome sequencing and prenatal imaging are increasing our ability to accurately recognize and diagnose Mendelian conditions prenatally. Phenotype-driven early genetic diagnosis of fetal genetic disease can help to strategize treatment options and clinical preventive measures during the perinatal period, to plan in utero therapies, and to inform parental decision-making. Fetal phenotypes of genetic diseases are often unique and at present are not well understood; more comprehensive knowledge about prenatal phenotypes and computational resources have an enormous potential to improve diagnostics and translational research. The Human Phenotype Ontology (HPO) has been widely used to support diagnostics and translational research in human genetics. To better support prenatal usage, the HPO consortium conducted a series of workshops with a group of domain experts in a variety of medical specialties, diagnostic techniques, as well as diseases and phenotypes related to prenatal medicine, including perinatal pathology, musculoskeletal anomalies, neurology, medical genetics, hydrops fetalis, craniofacial malformations, cardiology, neonatal-perinatal medicine, fetal medicine, placental pathology, prenatal imaging, and bioinformatics. We expanded the representation of prenatal phenotypes in HPO by adding 95 new phenotype terms under the Abnormality of prenatal development or birth (HP:0001197) grouping term, and revised definitions, synonyms, and disease annotations for most of the 152 terms that existed before the beginning of this effort. The expansion of prenatal phenotypes in HPO will support phenotype-driven prenatal exome and genome sequencing for precision genetic diagnostics of rare diseases to support prenatal care.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Technological advances in both genome sequencing and prenatal imaging are increasing our ability to accurately recognize and diagnose Mendelian conditions prenatally. Phenotype-driven early genetic diagnosis of fetal genetic disease can help to strategize treatment options and clinical preventive measures during the perinatal period, to plan in utero therapies, and to inform parental decision-making. Fetal phenotypes of genetic diseases are often unique and at present are not well understood; more comprehensive knowledge about prenatal phenotypes and computational resources have an enormous potential to improve diagnostics and translational research. The Human Phenotype Ontology (HPO) has been widely used to support diagnostics and translational research in human genetics. To better support prenatal usage, the HPO consortium conducted a series of workshops with a group of domain experts in a variety of medical specialties, diagnostic techniques, as well as diseases and phenotypes related to prenatal medicine, including perinatal pathology, musculoskeletal anomalies, neurology, medical genetics, hydrops fetalis, craniofacial malformations, cardiology, neonatal-perinatal medicine, fetal medicine, placental pathology, prenatal imaging, and bioinformatics. We expanded the representation of prenatal phenotypes in HPO by adding 95 new phenotype terms under the Abnormality of prenatal development or birth (HP:0001197) grouping term, and revised definitions, synonyms, and disease annotations for most of the 152 terms that existed before the beginning of this effort. The expansion of prenatal phenotypes in HPO will support phenotype-driven prenatal exome and genome sequencing for precision genetic diagnostics of rare diseases to support prenatal care.
Pattern-Based Logical Definitions of Prenatal Disorders Grounded on Dispositions
Ghosh, Mirna El; Ghazouani, Fethi; Akan, Elise; Charlet, Jean; Dhombres, Ferdinand
Dans: Stud Health Technol Inform, vol. 294, p. 347–351, 2022, ISSN: 1879-8365.
@article{pmid35612094,
title = {Pattern-Based Logical Definitions of Prenatal Disorders Grounded on Dispositions},
author = {Mirna El Ghosh and Fethi Ghazouani and Elise Akan and Jean Charlet and Ferdinand Dhombres},
doi = {10.3233/SHTI220472},
issn = {1879-8365},
year = {2022},
date = {2022-05-01},
journal = {Stud Health Technol Inform},
volume = {294},
pages = {347--351},
abstract = {Biomedical ontologies define concepts having biomedical significance and the semantic relations among them. Developing high-quality and reusable ontologies in the biomedical domain is a challenging task. Pattern-based ontology design is considered a promising approach to overcome the challenges. Ontology Design Patterns (ODPs) are reusable modeling solutions to facilitate ontology development. This study relies on ODPs to semantically enrich biomedical ontologies by assigning logical definitions to ontological entities. Specifically, pattern-based logical definitions grounded on dispositions are given to prenatal disorders. The proposed approach is performed under the supervision of fetal domain experts.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Biomedical ontologies define concepts having biomedical significance and the semantic relations among them. Developing high-quality and reusable ontologies in the biomedical domain is a challenging task. Pattern-based ontology design is considered a promising approach to overcome the challenges. Ontology Design Patterns (ODPs) are reusable modeling solutions to facilitate ontology development. This study relies on ODPs to semantically enrich biomedical ontologies by assigning logical definitions to ontological entities. Specifically, pattern-based logical definitions grounded on dispositions are given to prenatal disorders. The proposed approach is performed under the supervision of fetal domain experts.
Madec, F-X; Suply, E; Forin, V; Chamond, O; Lalanne, A; Irtan, S; Audry, G; Lallemant, P
Dans: Prog Urol, vol. 32, no. 5, p. 319–325, 2022, ISSN: 1166-7087.
@article{pmid34920919,
title = {Repeated detrusor injection of botulinum toxin A for neurogenic bladder in children: A long term option?},
author = {F-X Madec and E Suply and V Forin and O Chamond and A Lalanne and S Irtan and G Audry and P Lallemant},
doi = {10.1016/j.purol.2021.10.010},
issn = {1166-7087},
year = {2022},
date = {2022-04-01},
journal = {Prog Urol},
volume = {32},
number = {5},
pages = {319--325},
abstract = {AIMS: Evaluation of repeated (at least 4) intra-detrusor injections of toxin botulinum A (IDI-TBA) for neurogenic bladder in a pediatric cohort.nnMETHODS: Patients who underwent at least 4 IDI-TBA between 2005 and 2017 for neurogenic bladder related issues were included (detrusor overactivity and low compliance). Clinical and cystometric data were collected before and after the first injection and after the last injection. The primary endpoint was the proportion of patients with non-abnormal cystometry (no detrusor overactivity and normal compliance). Secondary outcomes were the evolution of the observed bladder capacity/expected ratio, surgical complications and acquired kidney impairment.nnRESULTS: From the 832 patients referred to our institution for neurogenic bladder, 48 underwent IDI-TBA, and 17 at least 4 injections. Among them, a total of 95 procedures were performed (median per patient 5 [4-8]). While the first injection had a significant effect for 82.3% patients, the last injection improved the medical condition for only 53.0% cases. The bladder capacity ratio, initially 36.1%, increased to 80.3% after the first injection but decreased to a level of 57.1% at last. After a median follow-up of 57 [34-102] months, no severe complications were reported but 11.8% of patients presented with repeated pyelonephritis. A bladder augmentation surgery was finally indicated for 35.3% cases.nnCONCLUSIONS: Despite a low complication rate and impressive cystometric results after the first injection, IDI-TBA efficacy decreased with time and repetition. These findings prone a long-term follow-up and a "à-la-carte" management of this specific population depending on the long-term response to IDI-TBA.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
AIMS: Evaluation of repeated (at least 4) intra-detrusor injections of toxin botulinum A (IDI-TBA) for neurogenic bladder in a pediatric cohort.nnMETHODS: Patients who underwent at least 4 IDI-TBA between 2005 and 2017 for neurogenic bladder related issues were included (detrusor overactivity and low compliance). Clinical and cystometric data were collected before and after the first injection and after the last injection. The primary endpoint was the proportion of patients with non-abnormal cystometry (no detrusor overactivity and normal compliance). Secondary outcomes were the evolution of the observed bladder capacity/expected ratio, surgical complications and acquired kidney impairment.nnRESULTS: From the 832 patients referred to our institution for neurogenic bladder, 48 underwent IDI-TBA, and 17 at least 4 injections. Among them, a total of 95 procedures were performed (median per patient 5 [4-8]). While the first injection had a significant effect for 82.3% patients, the last injection improved the medical condition for only 53.0% cases. The bladder capacity ratio, initially 36.1%, increased to 80.3% after the first injection but decreased to a level of 57.1% at last. After a median follow-up of 57 [34-102] months, no severe complications were reported but 11.8% of patients presented with repeated pyelonephritis. A bladder augmentation surgery was finally indicated for 35.3% cases.nnCONCLUSIONS: Despite a low complication rate and impressive cystometric results after the first injection, IDI-TBA efficacy decreased with time and repetition. These findings prone a long-term follow-up and a « à-la-carte » management of this specific population depending on the long-term response to IDI-TBA.
Dhombres, Ferdinand; Bonnard, Jules; Bailly, Kévin; Maurice, Paul; Papageorghiou, Aris T; Jouannic, Jean-Marie
Dans: J Med Internet Res, vol. 24, no. 4, p. e35465, 2022, ISSN: 1438-8871.
@article{pmid35297766,
title = {Contributions of Artificial Intelligence Reported in Obstetrics and Gynecology Journals: Systematic Review},
author = {Ferdinand Dhombres and Jules Bonnard and Kévin Bailly and Paul Maurice and Aris T Papageorghiou and Jean-Marie Jouannic},
doi = {10.2196/35465},
issn = {1438-8871},
year = {2022},
date = {2022-04-01},
journal = {J Med Internet Res},
volume = {24},
number = {4},
pages = {e35465},
abstract = {BACKGROUND: The applications of artificial intelligence (AI) processes have grown significantly in all medical disciplines during the last decades. Two main types of AI have been applied in medicine: symbolic AI (eg, knowledge base and ontologies) and nonsymbolic AI (eg, machine learning and artificial neural networks). Consequently, AI has also been applied across most obstetrics and gynecology (OB/GYN) domains, including general obstetrics, gynecology surgery, fetal ultrasound, and assisted reproductive medicine, among others.nnOBJECTIVE: The aim of this study was to provide a systematic review to establish the actual contributions of AI reported in OB/GYN discipline journals.nnMETHODS: The PubMed database was searched for citations indexed with "artificial intelligence" and at least one of the following medical subject heading (MeSH) terms between January 1, 2000, and April 30, 2020: "obstetrics"; "gynecology"; "reproductive techniques, assisted"; or "pregnancy." All publications in OB/GYN core disciplines journals were considered. The selection of journals was based on disciplines defined in Web of Science. The publications were excluded if no AI process was used in the study. Review, editorial, and commentary articles were also excluded. The study analysis comprised (1) classification of publications into OB/GYN domains, (2) description of AI methods, (3) description of AI algorithms, (4) description of data sets, (5) description of AI contributions, and (6) description of the validation of the AI process.nnRESULTS: The PubMed search retrieved 579 citations and 66 publications met the selection criteria. All OB/GYN subdomains were covered: obstetrics (41%, 27/66), gynecology (3%, 2/66), assisted reproductive medicine (33%, 22/66), early pregnancy (2%, 1/66), and fetal medicine (21%, 14/66). Both machine learning methods (39/66) and knowledge base methods (25/66) were represented. Machine learning used imaging, numerical, and clinical data sets. Knowledge base methods used mostly omics data sets. The actual contributions of AI were method/algorithm development (53%, 35/66), hypothesis generation (42%, 28/66), or software development (3%, 2/66). Validation was performed on one data set (86%, 57/66) and no external validation was reported. We observed a general rising trend in publications related to AI in OB/GYN over the last two decades. Most of these publications (82%, 54/66) remain out of the scope of the usual OB/GYN journals.nnCONCLUSIONS: In OB/GYN discipline journals, mostly preliminary work (eg, proof-of-concept algorithm or method) in AI applied to this discipline is reported and clinical validation remains an unmet prerequisite. Improvement driven by new AI research guidelines is expected. However, these guidelines are covering only a part of AI approaches (nonsymbolic) reported in this review; hence, updates need to be considered.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: The applications of artificial intelligence (AI) processes have grown significantly in all medical disciplines during the last decades. Two main types of AI have been applied in medicine: symbolic AI (eg, knowledge base and ontologies) and nonsymbolic AI (eg, machine learning and artificial neural networks). Consequently, AI has also been applied across most obstetrics and gynecology (OB/GYN) domains, including general obstetrics, gynecology surgery, fetal ultrasound, and assisted reproductive medicine, among others.nnOBJECTIVE: The aim of this study was to provide a systematic review to establish the actual contributions of AI reported in OB/GYN discipline journals.nnMETHODS: The PubMed database was searched for citations indexed with « artificial intelligence » and at least one of the following medical subject heading (MeSH) terms between January 1, 2000, and April 30, 2020: « obstetrics »; « gynecology »; « reproductive techniques, assisted »; or « pregnancy. » All publications in OB/GYN core disciplines journals were considered. The selection of journals was based on disciplines defined in Web of Science. The publications were excluded if no AI process was used in the study. Review, editorial, and commentary articles were also excluded. The study analysis comprised (1) classification of publications into OB/GYN domains, (2) description of AI methods, (3) description of AI algorithms, (4) description of data sets, (5) description of AI contributions, and (6) description of the validation of the AI process.nnRESULTS: The PubMed search retrieved 579 citations and 66 publications met the selection criteria. All OB/GYN subdomains were covered: obstetrics (41%, 27/66), gynecology (3%, 2/66), assisted reproductive medicine (33%, 22/66), early pregnancy (2%, 1/66), and fetal medicine (21%, 14/66). Both machine learning methods (39/66) and knowledge base methods (25/66) were represented. Machine learning used imaging, numerical, and clinical data sets. Knowledge base methods used mostly omics data sets. The actual contributions of AI were method/algorithm development (53%, 35/66), hypothesis generation (42%, 28/66), or software development (3%, 2/66). Validation was performed on one data set (86%, 57/66) and no external validation was reported. We observed a general rising trend in publications related to AI in OB/GYN over the last two decades. Most of these publications (82%, 54/66) remain out of the scope of the usual OB/GYN journals.nnCONCLUSIONS: In OB/GYN discipline journals, mostly preliminary work (eg, proof-of-concept algorithm or method) in AI applied to this discipline is reported and clinical validation remains an unmet prerequisite. Improvement driven by new AI research guidelines is expected. However, these guidelines are covering only a part of AI approaches (nonsymbolic) reported in this review; hence, updates need to be considered.
Pietton, Raphaël; Vialle, Raphaël; Laurent, Romain; Skalli, Wafa; Vergari, Claudio; Langlais, Tristan
Dans: Quant Imaging Med Surg, vol. 12, no. 3, p. 2184–2188, 2022, ISSN: 2223-4292.
@article{pmid35284266,
title = {Changes in quantitative elastography assessment of the adjacent lumbar disc after segmental fixation of the spine: a case description of a burst fracture of L4},
author = {Raphaël Pietton and Raphaël Vialle and Romain Laurent and Wafa Skalli and Claudio Vergari and Tristan Langlais},
doi = {10.21037/qims-21-666},
issn = {2223-4292},
year = {2022},
date = {2022-03-01},
journal = {Quant Imaging Med Surg},
volume = {12},
number = {3},
pages = {2184--2188},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
[The ethics of fetal myelomeningocele surgery]
Jouannic, J-M; Guilbaud, L; Maurice, P; Maisonneuve, E; de Saint Denis, T; du Peuty, C; Zerah, M
Dans: Gynecol Obstet Fertil Senol, vol. 50, no. 2, p. 189–193, 2022, ISSN: 2468-7189.
@article{pmid34656790,
title = {[The ethics of fetal myelomeningocele surgery]},
author = {J-M Jouannic and L Guilbaud and P Maurice and E Maisonneuve and T de Saint Denis and C du Peuty and M Zerah},
doi = {10.1016/j.gofs.2021.10.006},
issn = {2468-7189},
year = {2022},
date = {2022-02-01},
journal = {Gynecol Obstet Fertil Senol},
volume = {50},
number = {2},
pages = {189--193},
abstract = {Fetal myelomeningocele surgery was introduced in France in 2014. Developments in prenatal diagnosis of neural tube defects have accompanied the development of prenatal diagnosis. This fetal surgery represents one of the three possible care paths for pregnant women faced with this prenatal diagnosis. The ethical issues of this fetal surgery are discussed and in particular regarding prenatal counselling and patient autonomy of choice.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Fetal myelomeningocele surgery was introduced in France in 2014. Developments in prenatal diagnosis of neural tube defects have accompanied the development of prenatal diagnosis. This fetal surgery represents one of the three possible care paths for pregnant women faced with this prenatal diagnosis. The ethical issues of this fetal surgery are discussed and in particular regarding prenatal counselling and patient autonomy of choice.
Guilbaud, Lucie; Dugas, Anaïs; Weber, Mathilde; Deflers, Carole; Lallemant, Pauline; Lilin, Thomas; Adam, Clovis; Cras, Audrey; Mebarki, Miryam; Zérah, Michel; Faivre, Lionel; Larghero, Jérôme; Jouannic, Jean-Marie
Dans: Curr Res Transl Med, vol. 70, no. 1, p. 103314, 2022, ISSN: 2452-3186.
@article{pmid34731725,
title = {In utero treatment of myelomeningocele with allogenic umbilical cord-derived mesenchymal stromal cells in an ovine model},
author = {Lucie Guilbaud and Anaïs Dugas and Mathilde Weber and Carole Deflers and Pauline Lallemant and Thomas Lilin and Clovis Adam and Audrey Cras and Miryam Mebarki and Michel Zérah and Lionel Faivre and Jérôme Larghero and Jean-Marie Jouannic},
doi = {10.1016/j.retram.2021.103314},
issn = {2452-3186},
year = {2022},
date = {2022-01-01},
journal = {Curr Res Transl Med},
volume = {70},
number = {1},
pages = {103314},
abstract = {PURPOSE OF THE STUDY: The purpose of our study was to investigate the effects of ovine umbilical cord-derived mesenchymal stromal cells (UC-MSCs) seeded in a fibrin patch as an adjuvant therapy for fetal myelomeningocele repair in the ovine model.nnMATERIALS AND METHODS: MMC defects were surgically created at 75 days of gestation and repaired 15 days later with UC-MSCs patch or an acellular patch. At birth, motor function, tail movements, and voiding abilities were recorded. Histological and immunohistochemical analysis included study of MMC defect's healing, spinal cord, UC-MSCs survival, and screening for tumors.nnRESULTS: Six lambs were born alive in each group. There was no difference between the two groups on the median sheep locomotor rating score but all lambs in the control group had a score between lower than 3 compared to 50% in UC-MSCs group. There were more lambs with tail movements and voiding ability in UC-MSCs group (83% vs 0% and 50% vs 0%, respectively). gray matter area and large neurons density were higher in UC-MSCs group (2.5 vs 0.8 mm and 19.3 vs 1.6 neurons/mm of gray matter, respectively). Fibrosis thickness at the myelomeningocele scar level was reduced in UC-MSCs group (1269 µm vs 2624 µm). No tumors were observed.nnCONCLUSION: Fetal repair of myelomeningocele using allogenic UC-MSCs patch provides a moderate improvement in neurological functions, gray matter and neuronal preservation and prevented from fibrosis development at the myelomeningocele scar level.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
PURPOSE OF THE STUDY: The purpose of our study was to investigate the effects of ovine umbilical cord-derived mesenchymal stromal cells (UC-MSCs) seeded in a fibrin patch as an adjuvant therapy for fetal myelomeningocele repair in the ovine model.nnMATERIALS AND METHODS: MMC defects were surgically created at 75 days of gestation and repaired 15 days later with UC-MSCs patch or an acellular patch. At birth, motor function, tail movements, and voiding abilities were recorded. Histological and immunohistochemical analysis included study of MMC defect’s healing, spinal cord, UC-MSCs survival, and screening for tumors.nnRESULTS: Six lambs were born alive in each group. There was no difference between the two groups on the median sheep locomotor rating score but all lambs in the control group had a score between lower than 3 compared to 50% in UC-MSCs group. There were more lambs with tail movements and voiding ability in UC-MSCs group (83% vs 0% and 50% vs 0%, respectively). gray matter area and large neurons density were higher in UC-MSCs group (2.5 vs 0.8 mm and 19.3 vs 1.6 neurons/mm of gray matter, respectively). Fibrosis thickness at the myelomeningocele scar level was reduced in UC-MSCs group (1269 µm vs 2624 µm). No tumors were observed.nnCONCLUSION: Fetal repair of myelomeningocele using allogenic UC-MSCs patch provides a moderate improvement in neurological functions, gray matter and neuronal preservation and prevented from fibrosis development at the myelomeningocele scar level.
Pietton, Raphaël; Bouloussa, Houssam; Langlais, Tristan; Taytard, Jessica; Beydon, Nicole; Skalli, Wafa; Vergari, Claudio; Vialle, Raphaël
Dans: Bone Joint J, vol. 104-B, no. 1, p. 112–119, 2022, ISSN: 2049-4408.
@article{pmid34969276,
title = {Estimating pulmonary function after surgery for adolescent idiopathic scoliosis using biplanar radiographs of the chest with 3D reconstruction},
author = {Raphaël Pietton and Houssam Bouloussa and Tristan Langlais and Jessica Taytard and Nicole Beydon and Wafa Skalli and Claudio Vergari and Raphaël Vialle},
doi = {10.1302/0301-620X.104B1.BJJ-2021-0337.R2},
issn = {2049-4408},
year = {2022},
date = {2022-01-01},
journal = {Bone Joint J},
volume = {104-B},
number = {1},
pages = {112--119},
abstract = {AIMS: This study addressed two questions: first, does surgical correction of an idiopathic scoliosis increase the volume of the rib cage, and second, is it possible to evaluate the change in lung function after corrective surgery for adolescent idiopathic scoliosis (AIS) using biplanar radiographs of the ribcage with 3D reconstruction?nnMETHODS: A total of 45 patients with a thoracic AIS which needed surgical correction and fusion were included in a prospective study. All patients underwent pulmonary function testing (PFT) and low-dose biplanar radiographs both preoperatively and one year after surgery. The following measurements were recorded: forced vital capacity (FVC), slow vital capacity (SVC), and total lung capacity (TLC). Rib cage volume (RCV), maximum rib hump, main thoracic curve Cobb angle (MCCA), medial-lateral and anteroposterior diameter, and T4-T12 kyphosis were calculated from 3D reconstructions of the biplanar radiographs.nnRESULTS: All spinal and thoracic measurements improved significantly after surgery (p < 0.001). RCV increased from 4.9 l (SD 1) preoperatively to 5.3 l (SD 0.9) (p < 0.001) while TLC increased from 4.1 l (SD 0.9) preoperatively to 4.3 l (SD 0.8) (p < 0.001). RCV was correlated with all functional indexes before and after correction of the deformity. Improvement in RCV was weakly correlated with correction of the mean thoracic Cobb angle (p = 0.006). The difference in TLC was significantly correlated with changes in RCV (p = 0.041). It was possible to predict postoperative TLC from the postoperative RCV.nnCONCLUSION: 3D rib cage assessment from biplanar radiographs could be a minimally invasive method of estimating pulmonary function before and after spinal fusion in patients with an AIS. The 3D RCV reflects virtual chest capacity and hence pulmonary function in this group of patients. Cite this article: 2022;104-B(1):112-119.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
AIMS: This study addressed two questions: first, does surgical correction of an idiopathic scoliosis increase the volume of the rib cage, and second, is it possible to evaluate the change in lung function after corrective surgery for adolescent idiopathic scoliosis (AIS) using biplanar radiographs of the ribcage with 3D reconstruction?nnMETHODS: A total of 45 patients with a thoracic AIS which needed surgical correction and fusion were included in a prospective study. All patients underwent pulmonary function testing (PFT) and low-dose biplanar radiographs both preoperatively and one year after surgery. The following measurements were recorded: forced vital capacity (FVC), slow vital capacity (SVC), and total lung capacity (TLC). Rib cage volume (RCV), maximum rib hump, main thoracic curve Cobb angle (MCCA), medial-lateral and anteroposterior diameter, and T4-T12 kyphosis were calculated from 3D reconstructions of the biplanar radiographs.nnRESULTS: All spinal and thoracic measurements improved significantly after surgery (p < 0.001). RCV increased from 4.9 l (SD 1) preoperatively to 5.3 l (SD 0.9) (p < 0.001) while TLC increased from 4.1 l (SD 0.9) preoperatively to 4.3 l (SD 0.8) (p < 0.001). RCV was correlated with all functional indexes before and after correction of the deformity. Improvement in RCV was weakly correlated with correction of the mean thoracic Cobb angle (p = 0.006). The difference in TLC was significantly correlated with changes in RCV (p = 0.041). It was possible to predict postoperative TLC from the postoperative RCV.nnCONCLUSION: 3D rib cage assessment from biplanar radiographs could be a minimally invasive method of estimating pulmonary function before and after spinal fusion in patients with an AIS. The 3D RCV reflects virtual chest capacity and hence pulmonary function in this group of patients. Cite this article: 2022;104-B(1):112-119.
Langlais, T; Vergari, C; Xavier, F; Hawsawi, M Al; Gajny, L; Vialle, R; Skalli, W; Pietton, R
Dans: Med Eng Phys, vol. 99, p. 103735, 2022, ISSN: 1873-4030.
@article{pmid35058028,
title = {3D quasi-automatic spine length assessment using low dose biplanar radiography after surgical correction in thoracic idiopathic scoliosis},
author = {T Langlais and C Vergari and F Xavier and M Al Hawsawi and L Gajny and R Vialle and W Skalli and R Pietton},
doi = {10.1016/j.medengphy.2021.103735},
issn = {1873-4030},
year = {2022},
date = {2022-01-01},
journal = {Med Eng Phys},
volume = {99},
pages = {103735},
abstract = {OBJECTIVE: Surgical correction of thoracic scoliosis leads to a height improvement. Our objectives were to assess how the linear and developed spinal column lengths relate to the frontal and sagittal parameters after a surgical correction of thoracic idiopathic scoliosis, and whether the measurement of these lengths is reliable using quasi-automatic 3D reconstruction methods with biplanar X-rays.nnMETHODS: Consecutive children with thoracic idiopathic scoliosis who underwent spinal fusion surgery and biplanar pre and postoperative X-rays in free-standing position were included prospectively. Quasi-automatic computed 3D reconstructions of the spine were done using a previously validated technique and allowed the automatic computation of geometrical spinopelvic parameters including OD-pelvis, linear, and developed T1-T12 and T1-L5 lengths.nnRESULTS: Thirty patients with scoliosis were included, and 240 reconstructions were performed (2 operators x2 repetitions x30 patients pre and postoperative). The main thoracic Cobb angle, T1-T12, T1-L5 linear and developed distance, OD-pelvis were significantly improved (p < 0.001). The gain of the main thoracic Cobb angle (31.6°;SD = 9°) was correlated to the gain of the linear distance T1-T12 (15.3 mm;SD=7.3 mm)(rho = 0.76;p < 0.0001) and T1-L5 (24.7 mm;SD = 8 mm)(rho = 0.64;p < 0.0001). The postoperative change of developed length between T1-L5 represented 41% of the gain in linear distance between the same vertebrae. Similarly, the gain of T1-T12 developed length was 50% of linear T1-T12 height gain. Both differences were significant (p = 0.01). Absolute bias using Bland & Altman plots was lower than 1 mm for linear distance (0.1%) and lower than 2 mm (0.3%) for developed distance.nnCONCLUSION: The gain in spinal length is correlated to the thoracic Cobb angle correction in the surgical treatment of idiopathic thoracic scoliosis. The new significant finding is that the developed spinal height gain represented approximately a little less than 50% of the linear spinal height gain and these parameters were reliable from a 3D quasi-automatic reconstruction of biplanar X-ray.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
OBJECTIVE: Surgical correction of thoracic scoliosis leads to a height improvement. Our objectives were to assess how the linear and developed spinal column lengths relate to the frontal and sagittal parameters after a surgical correction of thoracic idiopathic scoliosis, and whether the measurement of these lengths is reliable using quasi-automatic 3D reconstruction methods with biplanar X-rays.nnMETHODS: Consecutive children with thoracic idiopathic scoliosis who underwent spinal fusion surgery and biplanar pre and postoperative X-rays in free-standing position were included prospectively. Quasi-automatic computed 3D reconstructions of the spine were done using a previously validated technique and allowed the automatic computation of geometrical spinopelvic parameters including OD-pelvis, linear, and developed T1-T12 and T1-L5 lengths.nnRESULTS: Thirty patients with scoliosis were included, and 240 reconstructions were performed (2 operators x2 repetitions x30 patients pre and postoperative). The main thoracic Cobb angle, T1-T12, T1-L5 linear and developed distance, OD-pelvis were significantly improved (p < 0.001). The gain of the main thoracic Cobb angle (31.6°;SD = 9°) was correlated to the gain of the linear distance T1-T12 (15.3 mm;SD=7.3 mm)(rho = 0.76;p < 0.0001) and T1-L5 (24.7 mm;SD = 8 mm)(rho = 0.64;p < 0.0001). The postoperative change of developed length between T1-L5 represented 41% of the gain in linear distance between the same vertebrae. Similarly, the gain of T1-T12 developed length was 50% of linear T1-T12 height gain. Both differences were significant (p = 0.01). Absolute bias using Bland & Altman plots was lower than 1 mm for linear distance (0.1%) and lower than 2 mm (0.3%) for developed distance.nnCONCLUSION: The gain in spinal length is correlated to the thoracic Cobb angle correction in the surgical treatment of idiopathic thoracic scoliosis. The new significant finding is that the developed spinal height gain represented approximately a little less than 50% of the linear spinal height gain and these parameters were reliable from a 3D quasi-automatic reconstruction of biplanar X-ray.