Publications

@article{pmid35940530,

title = {[Surgical experimental protocol of fetal myelomeningocele creation and repair in the ovine model (with video)]},

author = {Y Athiel and J-M Jouannic and L Guilbaud},

doi = {10.1016/j.gofs.2022.07.005},

issn = {2468-7189},

year  = {2022},

date = {2022-11-01},

journal = {Gynecol Obstet Fertil Senol},

volume = {50},

number = {11},

pages = {744--745},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid33845175,

title = {3D planning and patient-specific surgical guides in forearm osteotomy in children: Radiographic accuracy and clinical morbidity},

author = {Marie Benayoun and Tristan Langlais and Romain Laurent and Malo Le Hanneur and Raphaël Vialle and Manon Bachy and Franck Fitoussi},

doi = {10.1016/j.otsr.2021.102925},

issn = {1877-0568},

year  = {2022},

date = {2022-10-01},

journal = {Orthop Traumatol Surg Res},

volume = {108},

number = {6},

pages = {102925},

abstract = {INTRODUCTION: Three-dimensional (3D) planning and patient-specific surgical guides are increasingly used in the treatment of skeletal deformities. The present study hypothesis was that they are reliable in forearm osteotomy in children, with low morbidity.nnMATERIAL AND METHODS: Twenty-there children with one or several osteotomies to correct forearm deformities were retrospectively included: 9 (20 osteotomies) with surgical guide (G+), and 14 (28 osteotomies) without (G-). Etiologies comprised 8 cases of Madelung disease (3G+, 5G-) and 15 of post-traumatic malunion (6G+, 9G-). Mean age at surgery was 14.8±1.9 years. The patient-specific 3D-printed polyamide guides were produced from 3D virtual models based on 3D CT reconstruction. Mean follow-up was 22.1±13.6 months.nnRESULTS: Mean correction error was 5.3°±4.1 and 4.2°±4.1 in the frontal and sagittal planes respectively in G+ (p=0.6). Surgery time was significantly shorter in G+, by a mean 42min (p=0.02). Mean total radiation dose (preoperative CT+intraoperative fluoroscopy) was significantly higher in G+ (p<0.0001). Complications rates were similar between groups. Improvement in PRWE score was significantly greater in G+.nnCONCLUSION: The present preliminary results were encouraging. 3D planning and patient-specific surgical guides can be used in the treatment of forearm deformity in children.nnLEVEL OF EVIDENCE: III; retrospective cohort study.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35716985,

title = {Side bending radiographs and lowest instrumented vertebra in adolescent idiopathic scoliosis: A French quality-of-care study},

author = {Roxane Compagnon and Baptiste Brun-Cottan and Kariman Abelin-Genevois and Audrey Angelliaume and Emmanuelle Ferrero and Christophe Garin and Brice Ilharreborde and Jean-Luc Jouve and Yan Lefevre and Christian Morin and Raphaël Vialle and Franck Accadbled and Jérôme Sales de Gauzy and Sébastien Pesenti and Tristan Langlais},

doi = {10.1016/j.otsr.2022.103350},

issn = {1877-0568},

year  = {2022},

date = {2022-10-01},

journal = {Orthop Traumatol Surg Res},

volume = {108},

number = {6},

pages = {103350},

abstract = {BACKGROUND: Determining which spinal levels to instrument during surgical treatment of Lenke Type 1 adolescent idiopathic scoliosis (AIS) depends on the reducibility of the primary and secondary curve patterns. This reducibility can be evaluated in several ways, with the most popular being radiographs in bending for moderate thoracic and lumbar curvatures. Hypothesis Side-bending radiographs will alter the choice of the lowest instrumented vertebra (LIV) for the surgical treatment of AIS.nnMETHODS: Thirteen experienced French spine surgeons were invited to perform surgical planning on 23 patients based on stereoradiographs with and without (standing) side-bending views. The surgical planning was repeated a second time to assess the intra- and inter-rater reliability. Variations in the choice of LIV were analyzed for each evaluation.nnRESULTS: The intra-rater reliability was moderate to substantial. The inter-rater reliability was low to moderate. The study compared 879 surgical plans. Selective fusion was chosen in 0.3% of the plans. The median LIV was L2. The availability of side bending views changed the plan in 39% of cases. However, 36% of the plans were changed in the control (test-retest) condition. No significant difference was found between the variations with side-bending radiographs and "control" variations (p>0.05).nnCONCLUSION: The use of radiographs in bending has no significant effect on the LIV choice in this study. This result is derived from statistically robust analysis made possible by one of the largest datasets available on this topic. Large inter-rater variability was observed and will be explored further in a future study.nnLEVEL OF EVIDENCE: II; non-randomized controlled comparative study.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35841029,

title = {Biodistribution of allogenic umbilical cord-derived mesenchymal stromal cells after fetal repair of myelomeningocele in an ovine model},

author = {Yoann Athiel and Justine Nasone and Lousineh Arakelian and Lionel Faivre and Anaïs Dugas and Jean-Marie Jouannic and Jérôme Larghero and Lucie Guilbaud},

doi = {10.1186/s13287-022-02991-0},

issn = {1757-6512},

year  = {2022},

date = {2022-07-01},

journal = {Stem Cell Res Ther},

volume = {13},

number = {1},

pages = {300},

abstract = {BACKGROUND: Myelomeningocele (MMC) is a spinal cord congenital defect that leads to paraplegia, sphincter disorders and potential neurocognitive disabilities. Prenatal surgery of MMC provides a significant benefit compared to surgery at birth. Mesenchymal stromal cell (MSC) therapy as an adjuvant treatment for prenatal surgery showed promising results in animal experiments which could be considered for clinical use in human fetuses. Despite numerous reassuring studies on the safety of MSCs administration in humans, no study focused on MSCs biodistribution after a local MSCs graft on the fetal spinal cord.nnAIM: The purpose of our study was to assess the biodistribution of umbilical cord-derived mesenchymal stromal cells (UC-MSCs) at birth in lambs who had a prenatal myelomeningocele repair using a fibrin patch seeded with allogenic UC-MSCs.nnMETHODS: After isolation, UC-MSCs were tagged using a green fluorescent protein (GFP)-containing lentiviral vector. MMC defects were surgically created at 75 days of gestation and repaired 15 days later using UC-MSCs patch. Lambs were delivered at 142 days and sacrificed. DNA extraction was performed among biopsies of the different organs and q-PCR analysis was used to detect the expression of GFP (GFP DNA coding sequence).nnRESULTS: In our 6 surviving lambs grafted with UC-MSCs, GFP lentivirus genomic DNA was not detected in the organs.nnCONCLUSION: These reassuring data will support translational application in humans, especially since the first human clinical trial using mesenchymal stromal cells for in-utero treatment of MMC started recently in U.S.A.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35373593,

title = {A Preliminary Study to Assess the Relevance of Shear-Wave Elastography in Characterizing Biomechanical Changes in the Deltoid Ligament Complex in Relation to Ankle Position},

author = {Grégoire Rougereau and Thibault Marty-Diloy and Marie Vigan and Kalinka Donadieu and Alexandre Hardy and Raphaël Vialle and Tristan Langlais},

doi = {10.1177/10711007221079829},

issn = {1944-7876},

year  = {2022},

date = {2022-06-01},

journal = {Foot Ankle Int},

volume = {43},

number = {6},

pages = {840--849},

abstract = {BACKGROUND: The purpose of this study was (1) to evaluate the biomechanical properties of the different bundles of the deltoid ligament in various ankle positions in a cohort of healthy adult volunteers; (2) describe the impact of demographic and hindfoot morphology characteristics on their stiffness; (3) to assess the reliability and reproducibility of these measurements.nnMETHODS: Deltoid ligament complex of both ankles were assessed by shear-wave elastography (SWE) in 20 healthy patients resting on hinge support. The propagation shear-wave speed (SWS) in ligaments was measured, which is related to the tissue's elastic modulus. The following ligaments were analyzed in a neutral position and then in varus, valgus, dorsal, and plantar flexions: tibionavicular ligament (TNL), tibiocalcaneal ligament (TCL), the superficial posterior tibiotalar ligament (SPTL), the anterior tibiotalar ligament (ATTL), and the deep posterior tibiotalar ligament (DPTTL).nnRESULTS: The mean SWS increased between neutral and 20 degrees valgus position for TCL (4.08 ± 0.78 m/s vs 5.56 ± 0.62 m/s, respectively;  < .0001) and for DPTTL (2.58 ± 0.52 m/s vs 3.59 ± 0.87 m/s, respectively;  < .0001). The mean SWS increased between neutral and 30 degrees plantarflexion for ATTL (2.11 ± 0.44 m/s vs 3.1 ± 0.5 m/s, respectively;  < .0001) and TNL (2.96 ± 0.66 m/s vs 4.99 ± 0.69 m/s, respectively;  < .0001). The mean SWS increased between neutral and 20 degrees dorsal flexion for SPTL (4.2 ± 1 m/s vs 5.45 ± 0.65 m/s, respectively;  < .0001).Women had less DPTTL SWS than men in the neutral position (2.37 ± 0.35 m/s vs 2.71 ± 0.49 m/s, respectively;  = .007). Other demographics had no impact on the SWS value of other ligaments. All inter- and intraobserver agreements were good to excellent.nnCONCLUSION: This study presents a reliable and reproducible SWE measurement protocol to describe the physiological function of all bundles of the medial collateral ligament in healthy adults.nnCLINICAL RELEVANCE: This examination technique can be available to orthopaedic surgeons, allowing reliable and reproducible monitoring of the SWS of the various ligaments constituting the medial collateral plane. The biomechanical values described in this study may give insight into in what position medial ankle ligament reconstruction should be tensioned.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35872606,

title = {Prenatal phenotyping: A community effort to enhance the Human Phenotype Ontology},

author = {Ferdinand Dhombres and Patricia Morgan and Bimal P Chaudhari and Isabel Filges and Teresa N Sparks and Pablo Lapunzina and Tony Roscioli and Umber Agarwal and Shagun Aggarwal and Claire Beneteau and Pilar Cacheiro and Leigh C Carmody and Sophie Collardeau-Frachon and Esther A Dempsey and Andreas Dufke and Michael Henri Duyzend and Mirna El Ghosh and Jessica L Giordano and Ragnhild Glad and Ieva Grinfelde and Dominic G Iliescu and Markus S Ladewig and Monica C Munoz-Torres and Marzia Pollazzon and Francesca Clementina Radio and Carlota Rodo and Raquel Gouveia Silva and Damian Smedley and Jagadish Chandrabose Sundaramurthi and Sabrina Toro and Irene Valenzuela and Nicole A Vasilevsky and Ronald J Wapner and Roni Zemet and Melissa A Haendel and Peter N Robinson},

doi = {10.1002/ajmg.c.31989},

issn = {1552-4876},

year  = {2022},

date = {2022-06-01},

journal = {Am J Med Genet C Semin Med Genet},

volume = {190},

number = {2},

pages = {231--242},

abstract = {Technological advances in both genome sequencing and prenatal imaging are increasing our ability to accurately recognize and diagnose Mendelian conditions prenatally. Phenotype-driven early genetic diagnosis of fetal genetic disease can help to strategize treatment options and clinical preventive measures during the perinatal period, to plan in utero therapies, and to inform parental decision-making. Fetal phenotypes of genetic diseases are often unique and at present are not well understood; more comprehensive knowledge about prenatal phenotypes and computational resources have an enormous potential to improve diagnostics and translational research. The Human Phenotype Ontology (HPO) has been widely used to support diagnostics and translational research in human genetics. To better support prenatal usage, the HPO consortium conducted a series of workshops with a group of domain experts in a variety of medical specialties, diagnostic techniques, as well as diseases and phenotypes related to prenatal medicine, including perinatal pathology, musculoskeletal anomalies, neurology, medical genetics, hydrops fetalis, craniofacial malformations, cardiology, neonatal-perinatal medicine, fetal medicine, placental pathology, prenatal imaging, and bioinformatics. We expanded the representation of prenatal phenotypes in HPO by adding 95 new phenotype terms under the Abnormality of prenatal development or birth (HP:0001197) grouping term, and revised definitions, synonyms, and disease annotations for most of the 152 terms that existed before the beginning of this effort. The expansion of prenatal phenotypes in HPO will support phenotype-driven prenatal exome and genome sequencing for precision genetic diagnostics of rare diseases to support prenatal care.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35612094,

title = {Pattern-Based Logical Definitions of Prenatal Disorders Grounded on Dispositions},

author = {Mirna El Ghosh and Fethi Ghazouani and Elise Akan and Jean Charlet and Ferdinand Dhombres},

doi = {10.3233/SHTI220472},

issn = {1879-8365},

year  = {2022},

date = {2022-05-01},

journal = {Stud Health Technol Inform},

volume = {294},

pages = {347--351},

abstract = {Biomedical ontologies define concepts having biomedical significance and the semantic relations among them. Developing high-quality and reusable ontologies in the biomedical domain is a challenging task. Pattern-based ontology design is considered a promising approach to overcome the challenges. Ontology Design Patterns (ODPs) are reusable modeling solutions to facilitate ontology development. This study relies on ODPs to semantically enrich biomedical ontologies by assigning logical definitions to ontological entities. Specifically, pattern-based logical definitions grounded on dispositions are given to prenatal disorders. The proposed approach is performed under the supervision of fetal domain experts.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34920919,

title = {Repeated detrusor injection of botulinum toxin A for neurogenic bladder in children: A long term option?},

author = {F-X Madec and E Suply and V Forin and O Chamond and A Lalanne and S Irtan and G Audry and P Lallemant},

doi = {10.1016/j.purol.2021.10.010},

issn = {1166-7087},

year  = {2022},

date = {2022-04-01},

journal = {Prog Urol},

volume = {32},

number = {5},

pages = {319--325},

abstract = {AIMS: Evaluation of repeated (at least 4) intra-detrusor injections of toxin botulinum A (IDI-TBA) for neurogenic bladder in a pediatric cohort.nnMETHODS: Patients who underwent at least 4 IDI-TBA between 2005 and 2017 for neurogenic bladder related issues were included (detrusor overactivity and low compliance). Clinical and cystometric data were collected before and after the first injection and after the last injection. The primary endpoint was the proportion of patients with non-abnormal cystometry (no detrusor overactivity and normal compliance). Secondary outcomes were the evolution of the observed bladder capacity/expected ratio, surgical complications and acquired kidney impairment.nnRESULTS: From the 832 patients referred to our institution for neurogenic bladder, 48 underwent IDI-TBA, and 17 at least 4 injections. Among them, a total of 95 procedures were performed (median per patient 5 [4-8]). While the first injection had a significant effect for 82.3% patients, the last injection improved the medical condition for only 53.0% cases. The bladder capacity ratio, initially 36.1%, increased to 80.3% after the first injection but decreased to a level of 57.1% at last. After a median follow-up of 57 [34-102] months, no severe complications were reported but 11.8% of patients presented with repeated pyelonephritis. A bladder augmentation surgery was finally indicated for 35.3% cases.nnCONCLUSIONS: Despite a low complication rate and impressive cystometric results after the first injection, IDI-TBA efficacy decreased with time and repetition. These findings prone a long-term follow-up and a "à-la-carte" management of this specific population depending on the long-term response to IDI-TBA.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35297766,

title = {Contributions of Artificial Intelligence Reported in Obstetrics and Gynecology Journals: Systematic Review},

author = {Ferdinand Dhombres and Jules Bonnard and Kévin Bailly and Paul Maurice and Aris T Papageorghiou and Jean-Marie Jouannic},

doi = {10.2196/35465},

issn = {1438-8871},

year  = {2022},

date = {2022-04-01},

journal = {J Med Internet Res},

volume = {24},

number = {4},

pages = {e35465},

abstract = {BACKGROUND: The applications of artificial intelligence (AI) processes have grown significantly in all medical disciplines during the last decades. Two main types of AI have been applied in medicine: symbolic AI (eg, knowledge base and ontologies) and nonsymbolic AI (eg, machine learning and artificial neural networks). Consequently, AI has also been applied across most obstetrics and gynecology (OB/GYN) domains, including general obstetrics, gynecology surgery, fetal ultrasound, and assisted reproductive medicine, among others.nnOBJECTIVE: The aim of this study was to provide a systematic review to establish the actual contributions of AI reported in OB/GYN discipline journals.nnMETHODS: The PubMed database was searched for citations indexed with "artificial intelligence" and at least one of the following medical subject heading (MeSH) terms between January 1, 2000, and April 30, 2020: "obstetrics"; "gynecology"; "reproductive techniques, assisted"; or "pregnancy." All publications in OB/GYN core disciplines journals were considered. The selection of journals was based on disciplines defined in Web of Science. The publications were excluded if no AI process was used in the study. Review, editorial, and commentary articles were also excluded. The study analysis comprised (1) classification of publications into OB/GYN domains, (2) description of AI methods, (3) description of AI algorithms, (4) description of data sets, (5) description of AI contributions, and (6) description of the validation of the AI process.nnRESULTS: The PubMed search retrieved 579 citations and 66 publications met the selection criteria. All OB/GYN subdomains were covered: obstetrics (41%, 27/66), gynecology (3%, 2/66), assisted reproductive medicine (33%, 22/66), early pregnancy (2%, 1/66), and fetal medicine (21%, 14/66). Both machine learning methods (39/66) and knowledge base methods (25/66) were represented. Machine learning used imaging, numerical, and clinical data sets. Knowledge base methods used mostly omics data sets. The actual contributions of AI were method/algorithm development (53%, 35/66), hypothesis generation (42%, 28/66), or software development (3%, 2/66). Validation was performed on one data set (86%, 57/66) and no external validation was reported. We observed a general rising trend in publications related to AI in OB/GYN over the last two decades. Most of these publications (82%, 54/66) remain out of the scope of the usual OB/GYN journals.nnCONCLUSIONS: In OB/GYN discipline journals, mostly preliminary work (eg, proof-of-concept algorithm or method) in AI applied to this discipline is reported and clinical validation remains an unmet prerequisite. Improvement driven by new AI research guidelines is expected. However, these guidelines are covering only a part of AI approaches (nonsymbolic) reported in this review; hence, updates need to be considered.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35284266,

title = {Changes in quantitative elastography assessment of the adjacent lumbar disc after segmental fixation of the spine: a case description of a burst fracture of L4},

author = {Raphaël Pietton and Raphaël Vialle and Romain Laurent and Wafa Skalli and Claudio Vergari and Tristan Langlais},

doi = {10.21037/qims-21-666},

issn = {2223-4292},

year  = {2022},

date = {2022-03-01},

journal = {Quant Imaging Med Surg},

volume = {12},

number = {3},

pages = {2184--2188},

keywords = {},

pubstate = {published},

tppubtype = {article}

}